Drug comparisons
Canagliflozin vs Gliclazide
Compare Canagliflozin (Invokana, SGLT2i) vs Gliclazide (sulfonylurea) for type 2 diabetes: mechanisms, CV/renal benefits, hypo risk, weight effects, and safety.
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Clinical context
This comparison is triggered when choosing a second-line oral agent after metformin in type 2 diabetes, especially with CV disease, CKD, or hypoglycemia concerns.
Bottom line
Canagliflozin typically provides broader cardiorenal protection and metabolic advantages over Gliclazide, though cost and individual factors matter.
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