Drug comparisons
Canagliflozin vs Pioglitazone
Canagliflozin (Invokana) vs Pioglitazone (Actos) for diabetes. SGLT2 inhibitor vs TZD: which is better for blood sugar, weight, heart health, and safety?
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Clinical context
This comparison is triggered for type 2 diabetes patients needing add-on therapy after metformin, especially those with cardiovascular or kidney concerns versus marked insulin resistance.
Bottom line
Canagliflozin is often preferred for its extra heart, kidney, and weight benefits, though Pioglitazone may suit select insulin-resistant patients without heart failure risk.
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