Drug comparisons
Pioglitazone vs Repaglinide
Compare Pioglitazone vs Repaglinide for type 2 diabetes. TZD insulin sensitizer vs meglitinide: mechanism, side effects, black box HF vs hypo risk and dosing.
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Clinical context
Triggered when adding a second-line oral agent to metformin in type 2 diabetes patients with insulin resistance or need for prandial glucose control.
Bottom line
Pioglitazone suits insulin-resistant cases without heart failure, while Repaglinide offers flexible mealtime coverage at higher hypoglycemia risk.
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