Drug comparisons
Propafenone vs Encainide
Compare Propafenone vs Encainide, both class Ic antiarrhythmics. Rythmol still prescribed with warning; Encainide discontinued after CAST showed increased deaths.
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Clinical context
This comparison is triggered when evaluating class Ic antiarrhythmics for arrhythmias in patients with or without structural heart disease, referencing CAST trial data.
Bottom line
Propafenone is the only currently available option of the two, but both class Ic agents carry significant proarrhythmic risks.
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