Drug comparisons
Propoxyphene vs Pentazocine
Compare Propoxyphene vs Pentazocine: withdrawn opioid vs mixed agonist-antagonist. Propoxyphene banned for heart issues; Pentazocine has black-box warnings.
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Clinical context
Patients or clinicians comparing older opioid options for moderate pain after NSAIDs or acetaminophen have failed or when reviewing historical prescriptions.
Bottom line
Pentazocine is the only currently marketed choice of the two, yet both agents carry major safety liabilities that preclude routine use.
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