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Adrenocorticotropic Hormone (ACTH)

Published: July 27, 2026Updated: August 25, 2026

ACTH measures the level of adrenocorticotropic hormone in the blood, which stimulates cortisol production in the adrenal glands.

Quick summary

ACTH is a hormone that regulates cortisol production and is used to diagnose adrenal and pituitary disorders.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
pg/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche ACTH, Abbott ACTH, Siemens ACTH
interpretation: {"text":"May indicate primary adrenal insufficiency, ectopic ACTH syndrome, or a pituitary tumor.","label":"Elevated ACTH"}; {"text":"May suggest Cushing's syndrome, hypopituitarism, or exogenous steroid use.","label":"Low ACTH"}

Adrenocorticotropic Hormone (ACTH) is a hormone produced by the anterior pituitary gland that plays a crucial role in the regulation of cortisol, a steroid hormone produced by the adrenal glands.

The measurement of ACTH levels in the blood is primarily used to diagnose conditions related to the adrenal glands and the pituitary gland, such as Cushing's syndrome and Addison's disease.

Normal ACTH levels range from 10–60 pg/mL. Elevated levels may indicate primary adrenal insufficiency or a pituitary tumor, while low levels may suggest Cushing's syndrome or hypopituitarism.

Frequently asked questions

What are the symptoms of high ACTH levels?
Symptoms of high ACTH levels can include weight gain, muscle weakness, and mood changes.
How is an ACTH test performed?
An ACTH test involves drawing a blood sample, usually in the morning, as ACTH levels vary throughout the day.
  1. 1
    Mayo Clinic: ACTH TestSource
  2. 2
    Cleveland Clinic: Adrenocorticotropic HormoneSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy