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Asymmetric Dimethylarginine (ADMA)

Published: July 27, 2026Updated: August 25, 2026

ADMA is a naturally occurring amino acid that inhibits nitric oxide synthase, affecting vascular function and cardiovascular health.

Quick summary

ADMA is a biomarker for endothelial dysfunction and cardiovascular risk.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
μmol/L
Clinical utility
prognostic
Result kind
quantitative
FDA-cleared
Immunodiagnostic ADMA, Roche ADMA
interpretation: {"text":"ADMA levels within the reference range (0–0.55 μmol/L) suggest a lower risk of cardiovascular events.","label":"Low Risk"}; {"text":"ADMA levels above 0.55 μmol/L may indicate endothelial dysfunction and an increased risk of cardiovascular disease.","label":"High Risk"}

Asymmetric Dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), which plays a crucial role in regulating vascular tone and endothelial function. Elevated levels of ADMA are associated with impaired nitric oxide production, leading to endothelial dysfunction.

Research has shown that increased ADMA concentrations are linked to a higher risk of cardiovascular events, including hypertension, atherosclerosis, and heart failure. This makes ADMA a valuable prognostic marker for cardiovascular disease.

The normal reference range for ADMA is 0–0.55 μmol/L. Levels above this range may indicate an increased risk of cardiovascular complications and warrant further clinical evaluation.

Frequently asked questions

What is the role of ADMA in the body?
ADMA inhibits nitric oxide synthase, which affects the production of nitric oxide and consequently impacts vascular function and cardiovascular health.
How can ADMA levels be reduced?
Lifestyle changes such as a healthy diet, regular exercise, and medication prescribed by a healthcare provider can help reduce ADMA levels.
  1. 1
    ADMA as a Biomarker of Cardiovascular DiseaseSource
  2. 2
    Role of ADMA in Endothelial DysfunctionSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy