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Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA)

Published: July 27, 2026Updated: August 25, 2026

ADMA and SDMA are methylated derivatives of the amino acid arginine that serve as markers of endothelial dysfunction and kidney function, respectively.

Quick summary

ADMA and SDMA are biomarkers for cardiovascular and renal health.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
μmol/L
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche ADMA/SDMA, Immunodiagnostic ADMA/SDMA
interpretation: {"text":"0–1 μmol/L: Indicates a low risk of endothelial dysfunction and normal kidney function.","label":"Normal"}; {"text":">1 μmol/L: Suggests potential endothelial dysfunction and may indicate impaired kidney function.","label":"Elevated"}

ADMA and SDMA are amino acid derivatives that play significant roles in cardiovascular and renal physiology. Elevated levels of ADMA are associated with endothelial dysfunction, a precursor to cardiovascular diseases, while SDMA is a marker for kidney function and can indicate renal impairment.

These biomarkers are measured through blood tests and are crucial for assessing the risk of cardiovascular events and monitoring kidney health. They are particularly useful in patients with hypertension, diabetes, and chronic kidney disease.

Normal levels of ADMA and SDMA range from 0 to 1 μmol/L. Elevated levels may necessitate further diagnostic evaluation and intervention to manage cardiovascular and renal risks.

Frequently asked questions

What are the normal levels of ADMA and SDMA?
The normal range for both ADMA and SDMA is 0 to 1 μmol/L.
What do elevated levels of ADMA and SDMA indicate?
Elevated levels may indicate endothelial dysfunction and potential kidney impairment, suggesting a higher risk of cardiovascular events.
  1. 1
    Role of ADMA in Endothelial DysfunctionSource
  2. 2
    SDMA as a Marker of Renal FunctionSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy