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Anti-Cyclic Citrullinated Peptide IgA (Anti-CCP IgA)

Published: July 27, 2026Updated: August 25, 2026

Anti-CCP IgA is an antibody that targets citrullinated proteins and is used to diagnose rheumatoid arthritis and other inflammatory conditions.

Quick summary

Anti-CCP IgA is a diagnostic biomarker for rheumatoid arthritis and inflammatory diseases.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Anti-CCP IgA
interpretation: {"text":"0–20 U/mL: Negative for Anti-CCP IgA antibodies.","label":"Normal"}; {"text":">20 U/mL: Positive for Anti-CCP IgA antibodies, suggestive of rheumatoid arthritis or other inflammatory conditions.","label":"Elevated"}

Anti-Cyclic Citrullinated Peptide IgA (Anti-CCP IgA) is an antibody that binds to citrullinated proteins, which are proteins that have undergone a post-translational modification. This biomarker is primarily associated with rheumatoid arthritis (RA) and other inflammatory conditions.

The presence of Anti-CCP IgA antibodies in the blood can indicate the development of RA even before clinical symptoms appear. This makes it a valuable tool for early diagnosis and intervention.

Measuring Anti-CCP IgA levels can help differentiate RA from other types of arthritis and guide treatment strategies. Elevated levels are typically indicative of a more severe disease course.

Frequently asked questions

What is the normal range for Anti-CCP IgA?
The normal range for Anti-CCP IgA is 0–20 U/mL.
What does a high Anti-CCP IgA level indicate?
A high Anti-CCP IgA level indicates the presence of rheumatoid arthritis or other inflammatory conditions.
  1. 1
    Anti-CCP Antibodies in the Diagnosis of Rheumatoid ArthritisSource
  2. 2
    Role of Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid ArthritisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy