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Anti-Cyclic Citrullinated Peptide (Anti-CCP) High

Published: July 27, 2026Updated: August 25, 2026

This biomarker measures the level of anti-cyclic citrullinated peptide antibodies in the blood, which are often elevated in rheumatoid arthritis.

Quick summary

High levels of Anti-CCP indicate a strong likelihood of rheumatoid arthritis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Anti-CCP High, Abbott Anti-CCP High
interpretation: {"text":"0–20 U/mL: Negative for Anti-CCP antibodies, low likelihood of rheumatoid arthritis.","label":"Normal"}; {"text":">20 U/mL: Positive for Anti-CCP antibodies, high likelihood of rheumatoid arthritis.","label":"High"}

Anti-Cyclic Citrullinated Peptide (Anti-CCP) antibodies are autoantibodies that target citrullinated proteins in the body. Elevated levels of these antibodies are strongly associated with rheumatoid arthritis (RA), making Anti-CCP a valuable diagnostic tool.

The presence of Anti-CCP antibodies can often be detected before the onset of clinical symptoms, allowing for early diagnosis and intervention. This can be crucial in managing the disease and preventing joint damage.

A high Anti-CCP result, particularly above 20 U/mL, is highly specific for RA and can help differentiate it from other inflammatory conditions. This specificity makes it a preferred test in the diagnostic workup for suspected RA.

Frequently asked questions

What does a high Anti-CCP level mean?
A high Anti-CCP level, especially above 20 U/mL, strongly suggests the presence of rheumatoid arthritis.
Can Anti-CCP levels change over time?
Yes, Anti-CCP levels can fluctuate with disease activity, but they often remain elevated once positive.
  1. 1
    American College of RheumatologySource
  2. 2
    Mayo ClinicSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy