Skip to content

Anti-CCP IgA

Published: July 27, 2026Updated: August 25, 2026

Anti-CCP IgA measures the levels of Immunoglobulin A antibodies against cyclic citrullinated peptides, which are often elevated in rheumatoid arthritis.

Quick summary

Anti-CCP IgA is a diagnostic biomarker for rheumatoid arthritis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Anti-CCP IgA, Inova Anti-CCP IgA
interpretation: {"text":"0–20 U/mL: Negative for Anti-CCP IgA antibodies.","label":"Normal"}; {"text":">20 U/mL: Positive for Anti-CCP IgA antibodies, suggestive of rheumatoid arthritis.","label":"Elevated"}

Anti-CCP IgA is an antibody test that detects Immunoglobulin A antibodies targeting cyclic citrullinated peptides (CCP). These antibodies are highly specific for rheumatoid arthritis (RA) and can be detected in the early stages of the disease.

The presence of Anti-CCP IgA antibodies is strongly associated with more severe joint damage and a poorer prognosis in RA patients. This makes it a valuable tool for early diagnosis and intervention.

Measuring Anti-CCP IgA levels can help differentiate RA from other inflammatory joint diseases, guiding appropriate treatment strategies and improving patient outcomes.

Frequently asked questions

What is the normal range for Anti-CCP IgA?
The normal range for Anti-CCP IgA is typically between 0–20 U/mL.
How is an elevated Anti-CCP IgA level treated?
Elevated levels are typically treated with disease-modifying antirheumatic drugs (DMARDs) and other medications to manage symptoms and slow disease progression.
  1. 1
    Anti-CCP Antibodies in the Diagnosis of Rheumatoid ArthritisSource
  2. 2
    Role of Anti-CCP in the Diagnosis of Rheumatoid ArthritisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy