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Anti-Annexin Antibodies

Published: July 27, 2026Updated: August 25, 2026

Anti-Annexin antibodies are biomarkers that measure the immune system's response to Annexin proteins, which are involved in various cellular processes including inflammation.

Quick summary

Anti-Annexin antibodies are diagnostic markers for inflammatory conditions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
qualitative
FDA-cleared
Roche Anti-Annexin, Mitocheck Anti-Annexin
interpretation: {"text":"0–20 U/mL: Normal range, indicates no significant autoimmune or inflammatory response.","label":"Normal"}; {"text":">20 U/mL: May indicate an autoimmune or inflammatory condition, warranting further investigation.","label":"Elevated"}

Annexins are a family of proteins that play a role in membrane organization, regulation of inflammation, and cell signaling. Elevated levels of anti-Annexin antibodies can indicate an immune response against these proteins, often associated with autoimmune and inflammatory disorders.

The measurement of anti-Annexin antibodies is typically done through immunoassays, which quantify the concentration of these antibodies in the blood. Levels above the reference range (0–20 U/mL) may suggest an underlying inflammatory or autoimmune condition.

This biomarker is particularly useful in the diagnosis and monitoring of conditions such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and other autoimmune diseases where inflammation is a key component.

Frequently asked questions

What conditions are associated with elevated anti-Annexin antibodies?
Elevated levels are often associated with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis.
How is the anti-Annexin antibody test performed?
The test is performed using immunoassay techniques, typically on a blood sample.
  1. 1
    Annexin A2 and AutoimmunitySource
  2. 2
    Role of Annexins in InflammationSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy