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Anti-Cyclic Citrullinated Peptide (Anti-CCP)

Published: July 27, 2026Updated: August 25, 2026

Anti-CCP measures antibodies that target citrullinated proteins, which are often elevated in rheumatoid arthritis.

Quick summary

Anti-CCP is a key diagnostic marker for rheumatoid arthritis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Anti-CCP, Abbott Anti-CCP, Siemens Anti-CCP, Axis-Shield Anti-CCP
interpretation: {"text":"Levels below 20 U/mL are generally considered negative for Anti-CCP antibodies.","label":"Negative"}; {"text":"Levels above 20 U/mL may indicate the presence of rheumatoid arthritis or other autoimmune conditions.","label":"Positive"}

Anti-Cyclic Citrullinated Peptide (Anti-CCP) antibodies are autoantibodies that target proteins containing the amino acid citrulline. These antibodies are highly specific for rheumatoid arthritis (RA) and are present in the majority of patients with the disease.

The presence of Anti-CCP antibodies can often be detected years before the onset of clinical symptoms, making it a valuable tool for early diagnosis. This early detection can be crucial for implementing timely treatment strategies to manage the disease progression.

A positive Anti-CCP test in conjunction with clinical findings can help confirm a diagnosis of RA and differentiate it from other types of arthritis. The test is typically reported in units per milliliter (U/mL), with levels above 20 U/mL generally considered positive.

Frequently asked questions

What is the normal range for Anti-CCP?
The normal range for Anti-CCP is typically between 0–20 U/mL.
Can Anti-CCP levels change over time?
Yes, Anti-CCP levels can fluctuate with disease activity and treatment, but they often remain positive once elevated.
  1. 1
    Anti-CCP Antibodies in the Diagnosis of Rheumatoid ArthritisSource
  2. 2
    American College of Rheumatology: Anti-CCP TestingSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy