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Apolipoprotein A1

Published: July 27, 2026Updated: August 25, 2026

Apolipoprotein A1 (ApoA1) is a protein that is a major component of high-density lipoprotein (HDL), often referred to as 'good cholesterol.' It helps in removing cholesterol from tissues and arteries.

Quick summary

ApoA1 is a key protein in HDL cholesterol that aids in removing cholesterol from the body.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
mg/dL
Clinical utility
screening
Result kind
quantitative
FDA-cleared
Roche ApoA1, Abbott ApoA1, Siemens ApoA1
interpretation: {"text":"Levels below 120 mg/dL may indicate a higher risk of cardiovascular disease due to reduced cholesterol transport efficiency.","label":"Low"}; {"text":"Levels above 215 mg/dL are generally protective but should be evaluated in the context of overall lipid profile and health status.","label":"High"}

Apolipoprotein A1 (ApoA1) is a crucial protein component of high-density lipoprotein (HDL), commonly known as 'good cholesterol.' It plays a vital role in reverse cholesterol transport, a process that removes cholesterol from tissues and carries it to the liver for excretion.

Measuring ApoA1 levels can provide valuable insights into an individual's cardiovascular health. Lower levels of ApoA1 are associated with an increased risk of atherosclerosis and cardiovascular diseases, while higher levels are generally considered protective.

The reference range for ApoA1 is typically between 120–215 mg/dL. Deviations from this range may indicate an imbalance in lipid metabolism and could warrant further investigation or lifestyle modifications.

Frequently asked questions

What is the role of Apolipoprotein A1 in the body?
ApoA1 is essential for reverse cholesterol transport, helping to remove excess cholesterol from tissues and arteries to prevent plaque buildup.
How can I increase my Apolipoprotein A1 levels?
Regular exercise, a diet rich in healthy fats, and avoiding smoking can help increase ApoA1 levels and improve cardiovascular health.
  1. 1
    National Center for Biotechnology InformationSource
  2. 2
    American Heart AssociationSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy