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Anti-Saccharomyces cerevisiae IgG (ASCA-IgG)

Published: July 27, 2026Updated: August 25, 2026

ASCA-IgG measures the level of IgG antibodies against Saccharomyces cerevisiae, which is often elevated in inflammatory bowel diseases like Crohn's disease.

Quick summary

ASCA-IgG is a diagnostic marker for inflammatory bowel diseases.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche ASCA IgG, Vircell ASCA, Euroimmun ASCA IgG
interpretation: {"text":"0–20 U/mL: Normal range, low likelihood of inflammatory bowel disease.","label":"Normal"}; {"text":">20 U/mL: Possible indication of inflammatory bowel disease, particularly Crohn's disease.","label":"Elevated"}

ASCA-IgG is an antibody test that detects the presence of IgG antibodies against Saccharomyces cerevisiae, a type of yeast. Elevated levels of these antibodies are commonly associated with inflammatory bowel diseases (IBD), particularly Crohn's disease.

The test is useful in differentiating IBD from other gastrointestinal disorders and can aid in the diagnosis and management of Crohn's disease. It is often used in conjunction with other clinical findings and tests to provide a comprehensive diagnosis.

A reference range for ASCA-IgG is typically between 0–20 U/mL. Levels above this range may indicate the presence of IBD, but results should be interpreted in the context of the patient's overall clinical presentation.

Frequently asked questions

What is the purpose of the ASCA-IgG test?
The ASCA-IgG test is used to help diagnose inflammatory bowel diseases, especially Crohn's disease, by detecting antibodies against Saccharomyces cerevisiae.
What do high ASCA-IgG levels mean?
High levels of ASCA-IgG may indicate the presence of inflammatory bowel disease, particularly Crohn's disease, but should be interpreted alongside other clinical findings.
  1. 1
    Mayo Clinic: ASCA TestSource
  2. 2
    American College of Gastroenterology: Crohn's DiseaseSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy