Brain Natriuretic Peptide, proBNP
The proBNP biomarker is used to assess heart function and diagnose heart failure by measuring levels of this precursor hormone released by the heart ventricles in response to increased wall stress.
proBNP is a diagnostic biomarker for heart failure.
Key facts at a glance
- Units
- pg/mL
- Clinical utility
- diagnostic
- Result kind
- quantitative
- FDA-cleared
- Abbott i-STAT BNP Urgent
Pro-Brain Natriuretic Peptide (proBNP) is a precursor hormone produced by the heart ventricles in response to increased pressure and volume overload. Elevated levels of proBNP in the blood are indicative of heart dysfunction and can be used to diagnose heart failure.
The normal reference range for proBNP is typically between 0–450 pg/mL. Levels above this range suggest a higher likelihood of heart failure or other cardiovascular issues.
This biomarker is particularly useful in urgent care settings where rapid assessment of heart function is crucial for timely intervention and management of acute heart failure.
Frequently asked questions
What does a high proBNP level indicate?
Can proBNP levels change over time?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy