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Centromere Antibody

Published: July 27, 2026Updated: August 25, 2026

The centromere antibody test measures the presence and levels of antibodies targeting centromere proteins, which are crucial for proper cell division.

Quick summary

Centromere antibody test aids in diagnosing conditions like CREST syndrome and systemic sclerosis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Centromere, Abbott Centromere, Siemens Centromere
interpretation: {"text":"0–20 U/mL: Negative for centromere antibodies, indicating a lower likelihood of CREST syndrome.","label":"Normal"}; {"text":">20 U/mL: Positive for centromere antibodies, suggesting a higher likelihood of CREST syndrome or other related conditions.","label":"Elevated"}

Centromere antibodies are autoantibodies that target centromere proteins, which are essential components of the chromosome segregation machinery during cell division. These antibodies are commonly associated with limited cutaneous systemic sclerosis, also known as CREST syndrome.

The presence of centromere antibodies is a key diagnostic marker for CREST syndrome, which is characterized by calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. Elevated levels of these antibodies can also be found in other autoimmune conditions.

The centromere antibody test is a valuable tool in differentiating systemic sclerosis from other connective tissue disorders. It helps clinicians in making informed decisions about treatment strategies and disease management.

Frequently asked questions

What is the significance of a positive centromere antibody test?
A positive result indicates the presence of centromere antibodies, which are associated with CREST syndrome and other forms of systemic sclerosis.
Can centromere antibodies be detected in other autoimmune diseases?
Yes, although they are most commonly linked to CREST syndrome, centromere antibodies can also be found in other autoimmune conditions like primary biliary cholangitis.
  1. 1
    Centromere Antibodies - Lab Tests OnlineSource
  2. 2
    Systemic Sclerosis - Mayo ClinicSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy