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Chromogranin A

Published: July 27, 2026Updated: August 25, 2026

Chromogranin A is a protein released from neuroendocrine cells and is used as a biomarker to detect and monitor neuroendocrine tumors.

Quick summary

Chromogranin A is a key biomarker for diagnosing and monitoring neuroendocrine tumors.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
ng/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Chromogranin A, Abbott Chromogranin A, CIS Bio CgA
interpretation: {"text":"0–100 ng/mL: Normal range, indicating no immediate concern for neuroendocrine tumors.","label":"Normal"}; {"text":">100 ng/mL: May indicate the presence of a neuroendocrine tumor or other conditions affecting neuroendocrine cells.","label":"Elevated"}

Chromogranin A (CgA) is a protein found in the secretory granules of neuroendocrine cells. It is released into the bloodstream along with hormones and other substances.

Elevated levels of CgA in the blood can indicate the presence of neuroendocrine tumors, which are tumors that arise from cells of the endocrine and nervous systems.

The test is often used in conjunction with other diagnostic tools to confirm the diagnosis and to monitor the effectiveness of treatment.

Frequently asked questions

What conditions can cause elevated Chromogranin A levels?
Besides neuroendocrine tumors, conditions such as hypertension, chronic atrophic gastritis, and renal insufficiency can also cause elevated levels.
How is the Chromogranin A test performed?
The test is performed using a blood sample, which is typically collected from a vein in the arm.
  1. 1
    Mayo Clinic: Chromogranin A testSource
  2. 2
    American Cancer Society: Neuroendocrine TumorsSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy