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Copeptin

Published: July 27, 2026Updated: August 25, 2026

Copeptin is a surrogate marker for vasopressin and is used to assess cardiovascular stress and prognosis in patients with cardiovascular diseases.

Quick summary

Copeptin is a prognostic biomarker for cardiovascular stress and outcomes.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
pmol/L
Clinical utility
prognostic
Result kind
quantitative
FDA-cleared
Roche Copeptin, Brahms Copeptin
interpretation: {"text":"Indicates normal cardiovascular stress and lower risk of adverse outcomes.","label":"Low levels (0–12 pmol/L)"}; {"text":"Suggests increased cardiovascular stress and higher risk of adverse events such as heart failure and mortality.","label":"High levels (>12 pmol/L)"}

Copeptin is a 39-amino acid glycopeptide that is released in equimolar amounts with vasopressin (also known as antidiuretic hormone) from the posterior pituitary gland. It serves as a stable and easily measurable surrogate marker for vasopressin levels.

In the context of cardiovascular diseases, elevated copeptin levels indicate increased cardiovascular stress and have been associated with adverse outcomes such as heart failure, myocardial infarction, and mortality.

Measuring copeptin levels can help clinicians assess the prognosis of patients with cardiovascular conditions and guide treatment decisions to improve patient outcomes.

Frequently asked questions

What is the normal range for copeptin levels?
The normal range for copeptin levels is typically between 0–12 pmol/L.
How is copeptin measured?
Copeptin is measured through a blood test using immunoassays.
  1. 1
    Copeptin: A new vasopressin surrogate marker in cardiovascular diseaseSource
  2. 2
    Copeptin: Clinical use and potential as a prognostic markerSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy