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Corticotropin-releasing Hormone (CRH) Test

Published: July 27, 2026Updated: August 25, 2026

The CRH test measures the levels of corticotropin-releasing hormone in the blood to assess the functionality of the hypothalamic-pituitary-adrenal (HPA) axis.

Quick summary

CRH test evaluates the HPA axis by measuring corticotropin-releasing hormone levels.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
pg/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
FDA Cleared Reproductive Assay
interpretation: {"text":"May indicate hypopituitarism or secondary adrenal insufficiency.","label":"Low CRH"}; {"text":"Could suggest Cushing's syndrome or ectopic CRH production.","label":"High CRH"}

The CRH test is primarily used to diagnose disorders related to the hypothalamic-pituitary-adrenal (HPA) axis, such as Cushing's syndrome and adrenal insufficiency. This test involves administering CRH and then measuring the subsequent release of adrenocorticotropic hormone (ACTH) and cortisol.

Normal CRH levels typically range from 10–100 pg/mL. Deviations from this range can indicate issues with the HPA axis, such as overproduction or underproduction of hormones.

This test is crucial for diagnosing conditions like Cushing's syndrome, which is characterized by high cortisol levels, and Addison's disease, which involves low cortisol levels. It helps in understanding the root cause of hormonal imbalances.

Frequently asked questions

How is the CRH test performed?
The test involves an initial blood draw, followed by the administration of CRH and subsequent blood draws to measure hormone levels.
What are the risks of the CRH test?
Risks include bruising at the injection site, infection, and potential allergic reactions to the CRH injection.
  1. 1
    Corticotropin-releasing hormoneSource
  2. 2
    Hypothalamic-Pituitary-Adrenal AxisSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy