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Cerebrospinal Fluid Protein

Published: July 27, 2026Updated: August 25, 2026

Cerebrospinal fluid (CSF) protein measures the total amount of protein present in the CSF, which surrounds the brain and spinal cord. This biomarker is crucial for diagnosing conditions affecting the central nervous system.

Quick summary

CSF protein levels help diagnose neurological disorders by indicating potential disruptions in the blood-brain barrier.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
mg/dL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche CSF Protein, Abbott CSF Protein
interpretation: {"text":"Levels above 45 mg/dL may indicate infections, inflammation, or other disorders affecting the central nervous system.","label":"Elevated"}; {"text":"Levels below 15 mg/dL are rare but could suggest a CSF leak or a condition affecting protein production.","label":"Decreased"}

Cerebrospinal fluid (CSF) protein testing assesses the concentration of proteins in the CSF, which is vital for maintaining brain buoyancy and protecting the brain and spinal cord.

Elevated CSF protein levels can indicate conditions such as meningitis, encephalitis, or Guillain-Barré syndrome, while decreased levels are less common but can suggest a CSF leak.

The reference range for CSF protein is typically between 15–45 mg/dL, and deviations from this range can aid in the diagnosis and monitoring of various neurological disorders.

Frequently asked questions

What is the normal range for CSF protein?
The normal range for CSF protein is typically between 15–45 mg/dL.
What conditions can cause elevated CSF protein?
Elevated CSF protein can be caused by infections like meningitis, inflammatory conditions, or Guillain-Barré syndrome.
  1. 1
    Cerebrospinal Fluid AnalysisSource
  2. 2
    CSF Protein Levels in Neurological DisordersSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy