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Cystatin C eGFR

Published: July 27, 2026Updated: August 25, 2026

Cystatin C eGFR measures the estimated glomerular filtration rate (eGFR) using cystatin C levels to assess kidney function.

Quick summary

Cystatin C eGFR is a diagnostic marker for evaluating kidney function.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
mL/min/1.73m²
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Cystatin C eGFR, Abbott Cystatin C eGFR
interpretation: {"text":"60–120 mL/min/1.73m²: Normal kidney function.","label":"Normal"}; {"text":"<60 mL/min/1.73m²: Possible kidney disease or dysfunction.","label":"Abnormal"}

Cystatin C is a protein produced by all nucleated cells and is freely filtered by the glomerulus. Its blood levels are used to calculate the eGFR, providing an estimate of kidney function.

Unlike creatinine-based eGFR, cystatin C-based eGFR is less affected by muscle mass, age, and gender, making it a more reliable marker in certain populations.

A cystatin C eGFR between 60–120 mL/min/1.73m² is considered normal. Values below this range may indicate kidney dysfunction.

Frequently asked questions

How is cystatin C eGFR different from creatinine-based eGFR?
Cystatin C eGFR is less influenced by muscle mass and diet, making it more accurate in certain cases, especially for older adults and those with unusual body compositions.
What factors can affect cystatin C levels?
Inflammation, thyroid dysfunction, and certain medications can affect cystatin C levels, potentially impacting eGFR calculations.
  1. 1
    Cystatin C as a Biomarker of GFRSource
  2. 2
    National Kidney Foundation on eGFRSource
  3. 3
    Cystatin C eGFR: A More Accurate Measure of Kidney Function?Source

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy