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Deoxypyridinoline

Published: July 27, 2026Updated: August 25, 2026

Deoxypyridinoline is a crosslink molecule found in bone collagen and is used to assess bone resorption rates.

Quick summary

Deoxypyridinoline is a biomarker for bone resorption.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
nmol/mmolCr
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche DPD, Immunodiagnostic Systems DPD
interpretation: {"text":"DPD levels within the range of 3.5–13 nmol/mmolCr suggest normal bone resorption.","label":"Normal"}; {"text":"Levels above 13 nmol/mmolCr may indicate increased bone resorption, potentially due to osteoporosis, hyperparathyroidism, or other metabolic bone diseases.","label":"Elevated"}

Deoxypyridinoline (DPD) is a crosslink molecule that forms during the maturation of collagen in bones. It is released into the bloodstream and excreted in urine when bone is broken down.

Measuring DPD levels in urine helps in assessing the rate of bone resorption, which is crucial in diagnosing and monitoring metabolic bone diseases like osteoporosis.

The reference range for DPD is typically 3.5–13 nmol/mmolCr, and elevated levels may indicate increased bone turnover or conditions such as osteoporosis, hyperparathyroidism, or Paget's disease.

Frequently asked questions

What does a high DPD level mean?
A high DPD level indicates increased bone resorption, which can be a sign of conditions like osteoporosis or hyperparathyroidism.
How is the DPD test performed?
The DPD test is typically performed on a urine sample, often collected over a 24-hour period, to measure the amount of deoxypyridinoline present.
  1. 1
    Deoxypyridinoline as a Biomarker of Bone ResorptionSource
  2. 2
    Clinical Utility of Bone Turnover MarkersSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy