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Dehydroepiandrosterone Sulfate (DHEA-S)

Published: July 27, 2026Updated: August 25, 2026

DHEA-S is a hormone precursor produced by the adrenal glands, often used to assess adrenal function and androgen levels.

Quick summary

DHEA-S measures adrenal gland function and androgen levels.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
μmol/L
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche DHEA-S, Abbott DHEA-S, Siemens DHEA-S
interpretation: {"text":"May indicate adrenal insufficiency, hypopituitarism, or Addison's disease.","label":"Low Levels"}; {"text":"May suggest PCOS, adrenal tumors, or congenital adrenal hyperplasia.","label":"High Levels"}

DHEA-S, or Dehydroepiandrosterone Sulfate, is a hormone produced primarily by the adrenal glands. It serves as a precursor to more potent androgens like testosterone and is crucial for various bodily functions, including metabolism and immune response.

The measurement of DHEA-S in the blood is often used to evaluate adrenal gland function and to detect excess or deficient androgen production. This makes it a valuable diagnostic tool for conditions such as polycystic ovary syndrome (PCOS) and adrenal insufficiency.

Normal levels of DHEA-S range from 2–10 μmol/L. Levels outside this range can indicate various health issues, such as adrenal tumors, PCOS, or other endocrine disorders.

Frequently asked questions

What is the normal range for DHEA-S?
The normal range for DHEA-S is typically 2–10 μmol/L.
What conditions can cause abnormal DHEA-S levels?
Conditions such as PCOS, adrenal tumors, and adrenal insufficiency can cause abnormal DHEA-S levels.
  1. 1
    Mayo Clinic: DHEA-S TestSource
  2. 2
    MedlinePlus: DHEA-SSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy