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Estradiol

Published: July 27, 2026Updated: August 25, 2026

Estradiol is a form of estrogen, a primary female sex hormone, which plays a crucial role in the development of secondary sexual characteristics and regulation of the menstrual cycle.

Quick summary

Estradiol is a key hormone for reproductive health and fertility.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
pg/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Estradiol, Abbott Estradiol, Siemens Estradiol, Beckman Estradiol
interpretation: {"text":"May indicate menopause, ovarian failure, or hypopituitarism.","label":"Low Estradiol"}; {"text":"May suggest ovarian hyperstimulation, tumors, or estrogen-producing conditions.","label":"High Estradiol"}

Estradiol is the predominant form of estrogen in non-pregnant females and is essential for the growth of the uterus, fallopian tubes, and vagina.

Levels of estradiol vary throughout the menstrual cycle, peaking just before ovulation, and are crucial for fertility and bone health.

Abnormal levels of estradiol can indicate reproductive disorders, such as polycystic ovary syndrome (PCOS), ovarian tumors, or issues with the hypothalamic-pituitary-gonadal axis.

Frequently asked questions

What is a normal estradiol level?
Normal estradiol levels range from 30–400 pg/mL, but this can vary depending on age, menstrual cycle phase, and individual health status.
How is an estradiol test performed?
An estradiol test is a simple blood test, usually taken in the morning when hormone levels are at their peak.
  1. 1
    Estradiol - Lab Tests OnlineSource
  2. 2
    Estradiol Test - MedlinePlusSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy