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Fibrosis-4 (FIB-4) Score

Published: July 27, 2026Updated: August 25, 2026

The FIB-4 score is a non-invasive biomarker used to assess liver fibrosis, particularly in patients with chronic liver diseases such as hepatitis B and C, and non-alcoholic fatty liver disease.

Quick summary

The FIB-4 score helps diagnose and evaluate the severity of liver fibrosis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
score
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
FIB-4 Calculator, FIB-4 Index
interpretation: {"text":"FIB-4 score < 1.45: Low likelihood of significant liver fibrosis.","label":"Low Risk"}; {"text":"FIB-4 score > 3.25: High likelihood of advanced fibrosis or cirrhosis.","label":"High Risk"}

The FIB-4 score is calculated using a patient's age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelet count. It is a simple and cost-effective alternative to liver biopsy for assessing liver fibrosis.

A FIB-4 score below 1.45 generally indicates the absence of significant fibrosis, while a score above 3.25 suggests a high likelihood of advanced fibrosis or cirrhosis.

Despite its utility, the FIB-4 score is not definitive and should be used in conjunction with other clinical findings and diagnostic tests for a comprehensive assessment of liver health.

Frequently asked questions

What is a normal FIB-4 score?
A normal FIB-4 score is typically below 1.45, indicating a low risk of significant liver fibrosis.
Can FIB-4 scores change over time?
Yes, FIB-4 scores can change over time as liver health improves or worsens, making it a useful tool for monitoring disease progression.
  1. 1
    FIB-4 Score: A Simple Noninvasive Test to Identify Advanced Liver FibrosisSource
  2. 2
    FIB-4 Calculator and InterpretationSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy