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Glucose-6-Phosphate Dehydrogenase (G6PD) Activity

Published: July 27, 2026Updated: August 25, 2026

G6PD activity measures the level of the G6PD enzyme in red blood cells, which is crucial for protecting the cells from oxidative damage.

Quick summary

G6PD activity is a diagnostic test for assessing enzyme levels in red blood cells.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/gHb
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche G6PD, PointeSmart G6PD, Trinity G6PD
interpretation: {"text":"Indicates a deficiency in the G6PD enzyme, which may lead to hemolytic anemia.","label":"Low G6PD Activity"}; {"text":"Suggests normal enzyme function and no deficiency.","label":"Normal G6PD Activity"}

Glucose-6-Phosphate Dehydrogenase (G6PD) is an enzyme that plays a vital role in the normal functioning of red blood cells by protecting them from oxidative stress. The activity of this enzyme is essential for the production of NADPH, which is necessary for maintaining the integrity of the cell membrane.

A deficiency in G6PD can lead to hemolytic anemia, a condition where red blood cells are destroyed faster than they can be replaced. This test is crucial for diagnosing G6PD deficiency, especially in individuals with a family history of the condition or those who experience unexplained anemia.

The normal range for G6PD activity is typically between 0–13.5 U/gHb. Levels below this range may indicate a deficiency, while higher levels are generally not associated with any medical conditions.

Frequently asked questions

What are the symptoms of G6PD deficiency?
Symptoms may include jaundice, dark urine, fatigue, and shortness of breath, especially after exposure to certain triggers like infections or medications.
How is G6PD deficiency treated?
Treatment primarily involves avoiding triggers such as certain foods, medications, and infections. In severe cases, blood transfusions may be necessary.
  1. 1
    National Institutes of Health (NIH)Source
  2. 2
    Mayo ClinicSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy