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Glucose-6-Phosphate Dehydrogenase (G6PD) Screen

Published: July 27, 2026Updated: August 25, 2026

The G6PD screen measures the activity of the G6PD enzyme in red blood cells, which is crucial for protecting cells from oxidative damage.

Quick summary

G6PD screen assesses enzyme activity to diagnose deficiency.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/gHb
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche G6PD Screen, PointeSmart G6PD
interpretation: {"text":"Levels below 4.6 U/gHb may indicate G6PD deficiency, necessitating further testing and potential lifestyle modifications.","label":"Low"}; {"text":"Levels above 13.5 U/gHb are uncommon and may not be clinically significant without additional context.","label":"High"}

The G6PD enzyme is essential for the normal function of red blood cells, as it helps generate NADPH, which protects the cells from oxidative stress.

A deficiency in G6PD can lead to hemolytic anemia, particularly in response to certain medications, infections, or foods.

The G6PD screen is used to diagnose deficiency and guide treatment strategies to prevent hemolytic episodes.

Frequently asked questions

What are the symptoms of G6PD deficiency?
Symptoms can include anemia, jaundice, and dark urine, particularly after exposure to oxidative stressors.
How is G6PD deficiency treated?
Treatment primarily involves avoiding triggers such as certain medications, foods, and infections, and managing anemia if it occurs.
  1. 1
    G6PD Deficiency - National Institutes of HealthSource
  2. 2
    Mayo Clinic - G6PD DeficiencySource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy