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Galectin-3

Published: July 27, 2026Updated: August 25, 2026

Galectin-3 is a protein biomarker that measures inflammation and fibrosis in cardiovascular tissues. It is used to assess the risk of heart failure and adverse cardiovascular events.

Quick summary

Galectin-3 is a prognostic biomarker for heart failure and cardiovascular risk.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
ng/mL
Clinical utility
prognostic
Result kind
quantitative
FDA-cleared
Abbott Galectin-3, Roche Galectin-3
interpretation: {"text":"Galectin-3 levels within the reference range (0–25 ng/mL) suggest a lower risk of heart failure and adverse cardiovascular events.","label":"Low Risk"}; {"text":"Galectin-3 levels above 25 ng/mL may indicate an increased risk of heart failure progression and adverse cardiovascular outcomes.","label":"High Risk"}

Galectin-3 is a member of the lectin family and is involved in various biological processes, including inflammation, cell adhesion, and fibrosis. Elevated levels of galectin-3 in the blood are associated with increased fibrosis in the heart and other organs.

In the context of cardiovascular health, galectin-3 is particularly relevant for its role in the development and progression of heart failure. It is used to predict the risk of hospitalization and mortality in patients with heart failure.

The normal reference range for galectin-3 is typically between 0–25 ng/mL. Levels above this range may indicate a higher risk of adverse cardiovascular events and poorer prognosis.

Frequently asked questions

What is the role of galectin-3 in the body?
Galectin-3 is involved in inflammation, cell adhesion, and fibrosis, playing a crucial role in the development of heart failure and other cardiovascular conditions.
How is galectin-3 measured?
Galectin-3 is measured through a blood test, with levels typically reported in ng/mL.
  1. 1
    Galectin-3 as a Biomarker of Cardiovascular DiseaseSource
  2. 2
    Role of Galectin-3 in Heart FailureSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy