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High-Density Lipoprotein Cholesterol (HDL-C)

Published: July 27, 2026Updated: August 25, 2026

HDL-C measures the concentration of high-density lipoprotein cholesterol in the blood, which is often referred to as 'good' cholesterol due to its role in removing other forms of cholesterol from the bloodstream.

Quick summary

HDL-C is a measure of 'good' cholesterol that helps remove bad cholesterol from the blood.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
mg/dL
Clinical utility
screening
Result kind
quantitative
FDA-cleared
Roche HDL-C, Abbott HDL-C, Denka Seiken HDL-C
interpretation: {"text":"Levels below 40 mg/dL may indicate an increased risk of cardiovascular disease.","label":"Low HDL-C"}; {"text":"Levels above 60 mg/dL are generally considered protective against heart disease.","label":"High HDL-C"}

High-Density Lipoprotein Cholesterol (HDL-C) is a type of cholesterol often termed 'good' cholesterol because it helps carry cholesterol away from the arteries and back to the liver, where it can be processed and removed from the body.

HDL-C is an important biomarker in cardiovascular health screening because higher levels of HDL-C are generally associated with a lower risk of heart disease, as it helps to prevent the buildup of plaque in the arteries.

The reference range for HDL-C is typically between 40–60 mg/dL. Levels below 40 mg/dL may indicate a higher risk of cardiovascular disease, while levels above 60 mg/dL are generally considered protective.

Frequently asked questions

What is the role of HDL-C in the body?
HDL-C helps remove LDL cholesterol (bad cholesterol) from the bloodstream, reducing the risk of plaque buildup in the arteries.
How can I increase my HDL-C levels?
Regular exercise, a healthy diet rich in unsaturated fats, and avoiding smoking can help increase HDL-C levels.
  1. 1
    American Heart Association: HDL (Good) CholesterolSource
  2. 2
    Mayo Clinic: HDL cholesterol: How to boost your 'good' cholesterolSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy