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Hemolysis Index

Published: July 27, 2026Updated: August 25, 2026

The Hemolysis Index measures the level of hemoglobin released into the blood due to the breakdown of red blood cells.

Quick summary

Hemolysis Index assesses the extent of red blood cell destruction in the bloodstream.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
mg/dL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Sysmex Hemolysis Index, Abbott Hemolysis Index
interpretation: {"text":"0–50 mg/dL: No significant hemolysis detected.","label":"Normal"}; {"text":">50 mg/dL: Indicates potential hemolysis, warranting further evaluation.","label":"Elevated"}

The Hemolysis Index is a diagnostic tool used to determine the degree of hemolysis, which is the breakdown of red blood cells. Elevated levels of this biomarker can indicate conditions such as hemolytic anemia, autoimmune disorders, or infections that cause red blood cell destruction.

This index is particularly useful in clinical settings to differentiate between hemolysis and other causes of anemia. It helps in guiding further diagnostic tests and treatment strategies.

Normal values for the Hemolysis Index range from 0 to 50 mg/dL. Values above this range may suggest hemolysis, requiring additional investigations to identify the underlying cause.

Frequently asked questions

What causes elevated Hemolysis Index levels?
Elevated levels can be caused by conditions such as hemolytic anemia, autoimmune disorders, infections, or certain medications that lead to red blood cell destruction.
How is the Hemolysis Index measured?
The Hemolysis Index is typically measured through a blood test that quantifies the amount of free hemoglobin in the plasma.
  1. 1
    Hemolysis and the Hemolysis IndexSource
  2. 2
    Clinical Utility of Hemolysis IndexSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy