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Immunoglobulin A (IgA), Total

Published: July 27, 2026Updated: August 25, 2026

This biomarker measures the total amount of immunoglobulin A (IgA) in the blood, which is an antibody playing a crucial role in the immune response, particularly at mucosal surfaces.

Quick summary

Total IgA levels help assess immune system function and mucosal immunity.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
mg/dL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche IgA, Abbott IgA, Siemens IgA
interpretation: {"text":"May indicate selective IgA deficiency, which can increase susceptibility to infections, or other immune disorders.","label":"Low IgA"}; {"text":"Could suggest chronic infections, autoimmune diseases, or conditions like IgA multiple myeloma.","label":"High IgA"}

Immunoglobulin A (IgA) is a critical antibody in the immune system, primarily responsible for mucosal immunity, which defends against pathogens at the body's entry points like the respiratory and digestive tracts.

The total IgA test measures the overall concentration of IgA in the blood. Abnormal levels can indicate various immune disorders, including selective IgA deficiency or IgA multiple myeloma.

IgA levels are also monitored in patients with chronic inflammatory conditions or recurrent infections to evaluate the effectiveness of the immune response.

Frequently asked questions

What does a low IgA level mean?
A low IgA level may indicate a selective IgA deficiency, which can make individuals more susceptible to infections, particularly in mucosal tissues.
Can IgA levels change over time?
Yes, IgA levels can fluctuate due to infections, autoimmune conditions, or other immune responses, making it important to interpret results in the clinical context.
  1. 1
    Immunoglobulin A (IgA)Source
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    Total Immunoglobulin ASource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy