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Total Immunoglobulin E (IgE)

Published: July 27, 2026Updated: August 25, 2026

Total IgE measures the overall level of immunoglobulin E antibodies in the blood, which are associated with allergic responses and parasitic infections.

Quick summary

Total IgE is a diagnostic biomarker for allergies and parasitic infections.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
IU/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Total IgE, Abbott Total IgE, Siemens Total IgE, Phadia Total IgE
interpretation: {"text":"Levels below 0 IU/mL are not typical as IgE is normally present in the blood, even in small amounts.","label":"Low IgE"}; {"text":"Levels above 100 IU/mL may indicate an allergic response or a parasitic infection.","label":"High IgE"}

Immunoglobulin E (IgE) is a type of antibody produced by the immune system in response to allergens or parasitic infections. Elevated levels of total IgE are often indicative of an allergic condition or the presence of parasites in the body.

Common allergens that can trigger an increase in IgE levels include pollen, dust mites, pet dander, and certain foods. In addition, parasitic infections such as helminths can also lead to elevated IgE levels.

Measuring total IgE levels can help in the diagnosis of allergic disorders, such as asthma, allergic rhinitis, and atopic dermatitis. It can also aid in the detection of parasitic infections.

Frequently asked questions

What is a normal IgE level?
Normal IgE levels are typically between 0 and 100 IU/mL, but this can vary depending on the laboratory.
Can IgE levels change over time?
Yes, IgE levels can fluctuate based on exposure to allergens and the presence of infections.
  1. 1
    Total IgE: Reference Range, Interpretation, Collection and PanelsSource
  2. 2
    Immunoglobulin E (IgE) - Lab Tests OnlineSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy