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Interleukin-1 Beta

Published: July 27, 2026Updated: August 25, 2026

Interleukin-1 Beta (IL-1β) is a pro-inflammatory cytokine that plays a key role in the regulation of immune and inflammatory responses.

Quick summary

IL-1β is a biomarker for inflammation and is used to diagnose inflammatory conditions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
pg/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
R&D Systems IL-1beta ELISA, Meso Scale Discovery IL-1beta
interpretation: {"text":"IL-1β levels within the range of 0–5 pg/mL indicate no significant inflammation.","label":"Normal"}; {"text":"Levels above 5 pg/mL may suggest an inflammatory condition or infection.","label":"Elevated"}

Interleukin-1 Beta (IL-1β) is a cytokine that is produced by activated macrophages and is involved in the acute phase response to inflammation. It stimulates the production of other pro-inflammatory cytokines and mediators, contributing to the overall inflammatory response.

Elevated levels of IL-1β are associated with a variety of inflammatory and autoimmune conditions, including rheumatoid arthritis, gout, and sepsis. Measuring IL-1β levels can help in the diagnosis and monitoring of these conditions.

The normal reference range for IL-1β is typically between 0–5 pg/mL. Levels above this range may indicate an inflammatory response or an underlying condition that requires further investigation.

Frequently asked questions

What conditions can cause elevated IL-1β levels?
Elevated IL-1β levels can be caused by inflammatory conditions such as rheumatoid arthritis, gout, and sepsis.
How is the IL-1β test performed?
The IL-1β test is performed using a blood sample, which is analyzed in a laboratory to measure the concentration of the cytokine.
  1. 1
    Interleukin-1 BetaSource
  2. 2
    Role of IL-1 in inflammationSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy