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Laminin

Published: July 27, 2026Updated: August 25, 2026

Laminin is a glycoprotein that is a major component of the basal lamina, playing a crucial role in cell adhesion, differentiation, and migration. In the context of liver health, elevated levels can indicate liver fibrosis or cirrhosis.

Quick summary

Laminin is a biomarker used to assess liver fibrosis and cirrhosis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
ng/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Laminin, BioCode Laminin
interpretation: {"text":"0–130 ng/mL: Indicates a low likelihood of significant liver fibrosis or cirrhosis.","label":"Normal"}; {"text":">130 ng/mL: Suggests the presence of liver fibrosis or cirrhosis, warranting further clinical evaluation.","label":"Elevated"}

Laminin is a glycoprotein that is a key structural component of the basal lamina, a specialized form of extracellular matrix. It is essential for maintaining the structural integrity of tissues and organs, particularly in the liver.

In liver diseases, such as fibrosis and cirrhosis, the levels of laminin in the blood can increase due to the enhanced synthesis by activated hepatic stellate cells and the disrupted hepatic architecture.

Measuring laminin levels in the blood can aid in the diagnosis and monitoring of liver fibrosis and cirrhosis, providing valuable information about the extent of liver damage and the effectiveness of treatment interventions.

Frequently asked questions

What is the normal range for laminin levels in the blood?
The normal range for laminin levels in the blood is typically between 0–130 ng/mL.
What conditions can cause elevated laminin levels?
Elevated laminin levels can be caused by liver fibrosis, cirrhosis, and other conditions that affect liver architecture and function.
  1. 1
    Laminin as a Biomarker for Liver FibrosisSource
  2. 2
    Role of Laminin in Liver DiseaseSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy