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Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)

Published: July 27, 2026Updated: August 25, 2026

Lp-PLA2 is an enzyme that plays a role in the inflammation of blood vessels and is associated with the formation of atherosclerotic plaques.

Quick summary

Lp-PLA2 is a prognostic biomarker for cardiovascular risk assessment.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
ng/mL
Clinical utility
prognostic
Result kind
quantitative
FDA-cleared
PLAC Test LP-PLA2, Roche LP-PLA2
interpretation: {"text":"Lp-PLA2 levels below 200 ng/mL are generally considered to indicate a lower risk of cardiovascular events.","label":"Low Risk"}; {"text":"Lp-PLA2 levels above 200 ng/mL may suggest a higher risk of cardiovascular events and warrant further evaluation and management.","label":"High Risk"}

Lp-PLA2 is an enzyme that circulates in the blood and is primarily bound to low-density lipoprotein (LDL) particles. It is involved in the inflammatory processes within the arterial walls.

Elevated levels of Lp-PLA2 are associated with an increased risk of cardiovascular events, such as heart attacks and strokes, due to its role in the development of atherosclerosis.

Measuring Lp-PLA2 levels can help clinicians assess the risk of cardiovascular disease and guide treatment strategies, particularly in patients with intermediate risk profiles.

Frequently asked questions

What is the normal range for Lp-PLA2?
The normal range for Lp-PLA2 is typically considered to be between 0 and 200 ng/mL.
How can I lower my Lp-PLA2 levels?
Lifestyle changes such as adopting a heart-healthy diet, regular exercise, and medication can help lower Lp-PLA2 levels.
  1. 1
    Lp-PLA2 as a Biomarker of Cardiovascular DiseaseSource
  2. 2
    Role of Lp-PLA2 in Cardiovascular DiseaseSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy