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Metanephrines

Published: July 27, 2026Updated: August 25, 2026

Metanephrines are metabolites of adrenaline and noradrenaline, measured to diagnose pheochromocytoma and paraganglioma.

Quick summary

Metanephrines are biomarkers used to detect adrenal gland tumors.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
nmol/L
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Metanephrines, Abbott Metanephrines, Eureka Metanephrines
interpretation: {"text":"Metanephrine levels within the reference range (0–500 nmol/L) suggest no immediate indication of pheochromocytoma or paraganglioma.","label":"Normal"}; {"text":"Levels above 500 nmol/L may indicate the presence of a tumor and warrant further diagnostic evaluation.","label":"Elevated"}

Metanephrines are the metabolites of catecholamines, specifically adrenaline (epinephrine) and noradrenaline (norepinephrine). These compounds are produced by the adrenal glands and are excreted in the urine.

The measurement of metanephrines is crucial in the diagnosis of pheochromocytoma and paraganglioma, which are rare tumors of the adrenal glands and sympathetic nervous system.

Elevated levels of metanephrines in the blood or urine can indicate the presence of these tumors, which may cause symptoms such as high blood pressure, headaches, and excessive sweating.

Frequently asked questions

What is the normal range for metanephrines?
The normal range for metanephrines is typically 0–500 nmol/L.
How are metanephrines tested?
Metanephrines can be tested through blood or urine samples, usually collected over a 24-hour period.
  1. 1
    Mayo Clinic: MetanephrinesSource
  2. 2
    National Institutes of Health: Pheochromocytoma and ParagangliomaSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy