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Monoclonal Gammopathy of Undetermined Significance (MGUS) Screen

Published: July 27, 2026Updated: August 25, 2026

The MGUS screen measures the presence of abnormal monoclonal proteins in the blood, which can indicate the risk of developing multiple myeloma or related conditions.

Quick summary

The MGUS screen detects abnormal proteins in the blood to assess the risk of blood-related cancers.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
g/L
Clinical utility
screening
Result kind
qualitative
FDA-cleared
Helena SPE, Sebia Hydrasys
interpretation: {"text":"No detectable M-proteins in the blood (0 g/L).","label":"Normal"}; {"text":"Presence of M-proteins in the blood (above 0 g/L), indicating a need for further evaluation.","label":"Abnormal"}

MGUS is a condition characterized by the presence of an abnormal protein, known as a monoclonal protein or M-protein, in the blood. This condition is often asymptomatic and is usually detected during routine blood tests.

The screening test for MGUS involves measuring the levels of M-proteins, which are produced by a single clone of plasma cells. Elevated levels of these proteins can be indicative of MGUS, which may progress to more serious conditions like multiple myeloma.

Regular screening for MGUS is important for individuals at higher risk, such as older adults or those with a family history of blood-related cancers. Early detection can help in monitoring and managing the condition to prevent progression.

Frequently asked questions

What does a positive MGUS screen mean?
A positive MGUS screen indicates the presence of abnormal proteins in the blood, which may require further testing to determine the risk of progression to more serious conditions.
Is MGUS a type of cancer?
MGUS is not cancer, but it can increase the risk of developing certain types of blood cancers, such as multiple myeloma.
  1. 1
    Mayo Clinic - Monoclonal Gammopathy of Undetermined Significance (MGUS)Source
  2. 2
    American Cancer Society - Multiple Myeloma and Other Plasma Cell NeoplasmsSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy