Skip to content

Myeloperoxidase (MPO)

Published: July 27, 2026Updated: August 25, 2026

Myeloperoxidase (MPO) is an enzyme primarily released by neutrophils and is a marker of inflammation and oxidative stress, which are key factors in cardiovascular disease progression.

Quick summary

MPO is a prognostic biomarker for cardiovascular risk, indicating inflammation and oxidative stress.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
pmol/L
Clinical utility
prognostic
Result kind
quantitative
FDA-cleared
Abbott MPO, Roche MPO
interpretation: {"text":"MPO levels between 0–530 pmol/L are considered within the normal range, indicating a lower risk of cardiovascular events.","label":"Low Risk"}; {"text":"MPO levels above 530 pmol/L may suggest a higher risk of cardiovascular disease and warrant further evaluation and intervention.","label":"High Risk"}

Myeloperoxidase (MPO) is an enzyme found in neutrophils, which are a type of white blood cell. It plays a crucial role in the body's immune response by producing reactive oxygen species that help destroy pathogens.

In the context of cardiovascular health, elevated levels of MPO can indicate increased inflammation and oxidative stress, both of which contribute to the development and progression of atherosclerosis and other cardiovascular diseases.

Measuring MPO levels can provide valuable prognostic information, helping clinicians assess the risk of future cardiovascular events and guiding treatment strategies to reduce inflammation and oxidative damage.

Frequently asked questions

What is the normal range for MPO?
The normal reference range for MPO is typically 0–530 pmol/L.
How can I lower my MPO levels?
Lifestyle changes such as a healthy diet, regular exercise, and smoking cessation can help reduce inflammation and lower MPO levels.
  1. 1
    Myeloperoxidase and Cardiovascular DiseaseSource
  2. 2
    Role of MPO in AtherosclerosisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy