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Neuron-Specific Enolase (NSE) Panel

Published: July 27, 2026Updated: August 25, 2026

The NSE panel measures the levels of neuron-specific enolase, a glycolytic enzyme found in neurons and neuroendocrine cells, which can indicate the presence of certain cancers.

Quick summary

NSE is a biomarker used to diagnose and monitor neuroendocrine tumors and small cell lung cancer.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
ng/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche NSE, Abbott NSE, Fujirebio NSE
interpretation: {"text":"NSE levels within the range of 0–17 ng/mL are considered normal.","label":"Normal"}; {"text":"Levels above 17 ng/mL may indicate neuroendocrine tumors, small cell lung cancer, or other neurological conditions.","label":"Elevated"}

The Neuron-Specific Enolase (NSE) panel is a diagnostic test that quantifies the concentration of NSE in the blood. NSE is primarily found in neural tissue and neuroendocrine cells, making it a useful marker for conditions affecting these tissues.

Elevated levels of NSE are often associated with neuroendocrine tumors, small cell lung cancer (SCLC), and other neurological conditions. The test is particularly valuable for diagnosing and monitoring the progression of SCLC.

The reference range for NSE is typically between 0–17 ng/mL. Levels above this range may indicate the presence of a tumor or other pathological conditions, necessitating further investigation.

Frequently asked questions

What is the primary use of the NSE panel?
The NSE panel is primarily used to diagnose and monitor neuroendocrine tumors and small cell lung cancer.
What do elevated NSE levels indicate?
Elevated NSE levels may indicate the presence of neuroendocrine tumors, small cell lung cancer, or other neurological conditions.
  1. 1
    Neuron-Specific Enolase as a BiomarkerSource
  2. 2
    Clinical Utility of NSE in Lung CancerSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy