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Myeloperoxidase (MPO) - p-ANCA

Published: July 27, 2026Updated: August 25, 2026

The Myeloperoxidase (MPO) - p-ANCA biomarker measures the level of antibodies against myeloperoxidase, an enzyme found in neutrophils, which is often elevated in certain types of vasculitis and other inflammatory conditions.

Quick summary

MPO-pANCA is a diagnostic biomarker for vasculitis and inflammatory conditions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche MPO-ANCA, Abbott MPO-ANCA, Euroimmun MPO-ANCA
interpretation: {"text":"MPO-pANCA levels within the range of 0–20 U/mL are considered normal.","label":"Normal"}; {"text":"Levels above 20 U/mL may indicate the presence of vasculitis or other inflammatory conditions.","label":"Elevated"}

The Myeloperoxidase (MPO) - p-ANCA biomarker is used to detect the presence of anti-myeloperoxidase antibodies, which are characteristic of several autoimmune conditions, particularly microscopic polyangiitis and granulomatosis with polyangiitis.

Elevated levels of MPO-pANCA are often associated with systemic vasculitis, glomerulonephritis, and other inflammatory disorders, making it a crucial diagnostic tool for these conditions.

The reference range for MPO-pANCA is typically between 0–20 U/mL, and levels above this range may indicate the presence of an underlying inflammatory or autoimmune condition.

Frequently asked questions

What conditions can cause elevated MPO-pANCA levels?
Elevated MPO-pANCA levels are often associated with microscopic polyangiitis, granulomatosis with polyangiitis, and other systemic vasculitides.
How is the MPO-pANCA test performed?
The test is performed using a blood sample, which is analyzed for the presence of anti-myeloperoxidase antibodies.
  1. 1
    Myeloperoxidase and Anti-Myeloperoxidase AntibodiesSource
  2. 2
    Vasculitis: Diagnosis and ManagementSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy