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P-Selectin

Published: July 27, 2026Updated: August 25, 2026

P-Selectin is a cell adhesion molecule that measures platelet activation and endothelial dysfunction, which are crucial in cardiovascular diseases.

Quick summary

P-Selectin indicates platelet activation and endothelial dysfunction in cardiovascular conditions.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
ng/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche Soluble P-Selectin, R&D Systems P-Selectin ELISA
interpretation: {"text":"P-Selectin levels below 0 ng/mL are not physiologically possible as it indicates the absence of the biomarker.","label":"Low levels"}; {"text":"P-Selectin levels above 50 ng/mL may suggest increased platelet activation and endothelial dysfunction, potentially indicating cardiovascular disease.","label":"High levels"}

P-Selectin, also known as CD62P, is a glycoprotein found in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. It plays a key role in the early stages of atherosclerosis by mediating the interaction between platelets, endothelial cells, and leukocytes.

Elevated levels of P-Selectin in the blood are associated with increased platelet activation and endothelial dysfunction, which are common in conditions such as acute coronary syndrome, hypertension, and stroke.

Measuring P-Selectin levels can aid in the diagnosis and management of cardiovascular diseases, providing insights into the underlying inflammatory and thrombotic processes.

Frequently asked questions

What is the normal range for P-Selectin?
The normal range for P-Selectin is typically between 0–50 ng/mL.
How is P-Selectin measured?
P-Selectin is measured through a blood test, often using enzyme-linked immunosorbent assay (ELISA) techniques.
  1. 1
    P-Selectin and Cardiovascular DiseaseSource
  2. 2
    Role of P-Selectin in AtherosclerosisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy