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Prothrombin G20210A

Published: July 27, 2026Updated: August 25, 2026

The Prothrombin G20210A biomarker measures a specific genetic mutation in the F2 gene, which is associated with increased levels of prothrombin and a higher risk of blood clots.

Quick summary

Prothrombin G20210A is a genetic mutation that increases the risk of thrombosis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
genotype
Clinical utility
predictive
Result kind
qualitative
FDA-cleared
Roche Factor II PCR, Cepheid Factor II
interpretation: {"text":"Presence of the G20210A mutation indicates an increased risk of thrombosis.","label":"Positive"}; {"text":"Absence of the G20210A mutation suggests a lower risk of thrombosis due to this specific genetic factor.","label":"Negative"}

Prothrombin G20210A is a genetic variant in the F2 gene, which encodes prothrombin, a key protein in the blood coagulation cascade. This mutation leads to elevated levels of prothrombin, thereby increasing the risk of venous thrombosis.

The presence of the G20210A variant is identified through genetic testing, which is crucial for individuals with a family history of thrombotic events or those who have experienced unexplained thrombosis.

Understanding the presence of this mutation can guide clinical decisions regarding anticoagulant therapy and lifestyle modifications to reduce the risk of future thrombotic events.

Frequently asked questions

What is the clinical significance of the Prothrombin G20210A mutation?
The mutation increases the risk of venous thrombosis and may influence decisions regarding anticoagulation therapy.
How is the Prothrombin G20210A mutation inherited?
It is inherited in an autosomal dominant pattern, meaning one copy of the mutated gene is sufficient to increase thrombosis risk.
  1. 1
    Genetics Home Reference: Prothrombin G20210ASource
  2. 2
    Mayo Clinic: Prothrombin G20210A mutationSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy