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Rheumatoid Factor IgA

Published: July 27, 2026Updated: August 25, 2026

Rheumatoid Factor IgA (RF-IgA) is an antibody that targets the Fc portion of IgG and is associated with inflammatory conditions, particularly rheumatoid arthritis.

Quick summary

RF-IgA is an inflammatory biomarker used to diagnose rheumatoid arthritis.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
IU/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche RF IgA, Inova RF IgA
interpretation: {"text":"0–20 IU/mL: Levels within this range are generally considered normal and are not indicative of rheumatoid arthritis or other inflammatory conditions.","label":"Normal"}; {"text":">20 IU/mL: Elevated levels may suggest the presence of rheumatoid arthritis or other inflammatory conditions and should be evaluated further.","label":"Elevated"}

Rheumatoid Factor IgA (RF-IgA) is a type of antibody that is part of the larger family of rheumatoid factors, which are autoantibodies that target the Fc portion of IgG immunoglobulins.

Elevated levels of RF-IgA in the blood are often indicative of inflammatory conditions, most notably rheumatoid arthritis, but can also be associated with other autoimmune disorders.

Measurement of RF-IgA is typically used in conjunction with other diagnostic tools to confirm the presence of rheumatoid arthritis and to monitor disease activity.

Frequently asked questions

What is the normal range for RF-IgA?
The normal range for RF-IgA is typically 0–20 IU/mL.
What conditions are associated with elevated RF-IgA levels?
Elevated RF-IgA levels are commonly associated with rheumatoid arthritis and other autoimmune inflammatory conditions.
  1. 1
    Rheumatoid Factor (RF) TestSource
  2. 2
    Autoimmune Diseases and Rheumatoid FactorSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy