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Sex Hormone Binding Globulin (SHBG)

Published: July 27, 2026Updated: August 25, 2026

SHBG is a protein that binds to sex hormones, including testosterone and estradiol, and regulates their bioavailability in the bloodstream.

Quick summary

SHBG measures the level of a protein that binds to sex hormones, affecting their availability in the body.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
nmol/L
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche SHBG, Abbott SHBG, Siemens SHBG
interpretation: {"text":"May indicate conditions such as obesity, insulin resistance, or hyperandrogenism.","label":"Low SHBG"}; {"text":"May suggest hyperthyroidism, liver disease, or estrogen excess.","label":"High SHBG"}

Sex Hormone Binding Globulin (SHBG) is a glycoprotein that binds to sex hormones such as testosterone and estradiol, thereby regulating their bioavailability and activity in the body.

SHBG levels can be used to assess hormonal imbalances, particularly in conditions like polycystic ovary syndrome (PCOS), hypogonadism, and thyroid disorders.

The reference range for SHBG is typically between 10–80 nmol/L, and deviations from this range can indicate underlying health issues.

Frequently asked questions

What factors can affect SHBG levels?
Factors such as age, sex, liver function, thyroid function, and certain medications can influence SHBG levels.
How is an SHBG test performed?
An SHBG test is a simple blood test, usually performed in a clinical setting, and does not require any special preparation.
  1. 1
    Sex Hormone Binding Globulin (SHBG) - Lab Tests OnlineSource
  2. 2
    SHBG: The Test | SHBG Blood Test - MedlinePlusSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy