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Sjögren's Syndrome Antibody A (SSA)

Published: July 27, 2026Updated: August 25, 2026

The Sjögren's Syndrome Antibody A (SSA) biomarker measures the presence of anti-SSA/Ro antibodies, which are associated with autoimmune conditions like Sjögren's syndrome and systemic lupus erythematosus.

Quick summary

SSA antibodies are used to diagnose Sjögren's syndrome and other autoimmune disorders.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche SSA, Abbott SSA, Siemens SSA, Inova SSA
interpretation: {"text":"0–20 U/mL: Negative for SSA antibodies, unlikely to have Sjögren's syndrome or related conditions.","label":"Normal"}; {"text":">20 U/mL: Positive for SSA antibodies, suggestive of Sjögren's syndrome or other autoimmune disorders.","label":"Elevated"}

The SSA biomarker is crucial in the diagnosis of Sjögren's syndrome, an autoimmune condition characterized by dry eyes and mouth, as well as other systemic symptoms. Elevated levels of anti-SSA/Ro antibodies are often found in patients with this condition.

In addition to Sjögren's syndrome, the presence of SSA antibodies can also indicate systemic lupus erythematosus (SLE). These antibodies are part of a broader panel of tests used to differentiate between various autoimmune disorders.

The diagnostic utility of the SSA biomarker is significant, as it helps clinicians identify and manage autoimmune conditions. A result above the reference range (0–20 U/mL) may warrant further investigation or a change in treatment strategy.

Frequently asked questions

What is the normal range for SSA antibodies?
The normal range for SSA antibodies is 0–20 U/mL.
What conditions are associated with elevated SSA levels?
Elevated SSA levels are associated with Sjögren's syndrome and systemic lupus erythematosus (SLE).
  1. 1
    Sjögren's Syndrome FoundationSource
  2. 2
    American College of RheumatologySource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy