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Anti-SS-B (La) Antibodies

Published: July 27, 2026Updated: August 25, 2026

The Anti-SS-B (La) Antibodies test measures the levels of antibodies directed against the SS-B (La) antigen, which is often associated with autoimmune conditions like Sjögren's syndrome.

Quick summary

This test helps diagnose Sjögren's syndrome and other autoimmune disorders.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
U/mL
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche SSB, Abbott SSB, Siemens SSB, Inova SSB
interpretation: {"text":"0–20 U/mL: Normal levels, suggesting a lower likelihood of autoimmune conditions like Sjögren's syndrome.","label":"Normal"}; {"text":">20 U/mL: Elevated levels may indicate the presence of Sjögren's syndrome or other autoimmune disorders.","label":"Elevated"}

Anti-SS-B (La) antibodies are a type of autoantibody that target the SS-B (La) antigen, a protein involved in RNA processing. Elevated levels of these antibodies are frequently found in patients with Sjögren's syndrome, an autoimmune condition characterized by dry eyes and mouth.

In addition to Sjögren's syndrome, elevated Anti-SS-B (La) antibodies can also be present in other autoimmune diseases such as systemic lupus erythematosus (SLE). The presence of these antibodies can aid in the differential diagnosis of these conditions.

The normal reference range for Anti-SS-B (La) antibodies is typically between 0–20 U/mL. Results above this range may indicate the presence of an autoimmune disorder, though further clinical evaluation is necessary for a definitive diagnosis.

Frequently asked questions

What is the primary use of the Anti-SS-B (La) Antibodies test?
The test is primarily used to aid in the diagnosis of Sjögren's syndrome and other autoimmune disorders.
Can other conditions cause elevated Anti-SS-B (La) antibodies?
Yes, conditions like systemic lupus erythematosus (SLE) can also result in elevated levels of these antibodies.
  1. 1
    Mayo Clinic: Sjögren's SyndromeSource
  2. 2
    MedlinePlus: Anti-SS-B (La) AntibodiesSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy