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Soluble Transferrin Receptor

Published: July 27, 2026Updated: August 25, 2026

This biomarker measures the concentration of soluble transferrin receptor (sTfR) in the blood, which reflects the body's iron status and erythropoietic activity.

Quick summary

sTfR levels indicate iron deficiency and erythropoietic activity.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
mg/L
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche sTfR, R&D Systems sTfR ELISA
interpretation: {"text":"Levels above 2.3 mg/L may indicate iron deficiency anemia or increased erythropoietic activity.","label":"Elevated"}; {"text":"Levels below the reference range may suggest reduced erythropoiesis or iron overload.","label":"Decreased"}

The soluble transferrin receptor (sTfR) is a truncated form of the membrane-bound transferrin receptor, which is released into the blood. It is a sensitive indicator of iron deficiency and can help distinguish between iron deficiency anemia and anemia of chronic disease.

Elevated levels of sTfR are typically associated with iron deficiency anemia, increased erythropoietic activity, or conditions like hemolytic anemia. Conversely, lower levels may indicate reduced erythropoiesis or iron overload.

The reference range for sTfR is generally 0–2.3 mg/L. Measurements outside this range can guide further diagnostic workup and treatment strategies for various hematological conditions.

Frequently asked questions

What is the normal range for sTfR?
The normal range for soluble transferrin receptor is typically 0–2.3 mg/L.
What conditions can cause elevated sTfR levels?
Iron deficiency anemia, hemolytic anemia, and increased erythropoietic activity can cause elevated sTfR levels.
  1. 1
    Transferrin Receptor Levels in Health and DiseaseSource
  2. 2
    Clinical Utility of Soluble Transferrin ReceptorSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy