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Soluble Suppression of Tumorigenicity 2 (sST2)

Published: July 27, 2026Updated: August 25, 2026

sST2 is a prognostic biomarker that measures levels of a soluble form of the ST2 protein, which is involved in inflammatory and fibrotic processes in cardiovascular diseases.

Quick summary

sST2 is a prognostic biomarker for cardiovascular diseases, reflecting inflammatory and fibrotic activity.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
ng/mL
Clinical utility
prognostic
Result kind
quantitative
FDA-cleared
Roche Elecsys sST2, Critical Diagnostics ST2
interpretation: {"text":"sST2 levels within the reference range (0–35 ng/mL) suggest a lower risk of adverse cardiovascular events.","label":"Low Risk"}; {"text":"sST2 levels above 35 ng/mL may indicate a higher risk of heart failure and other cardiovascular complications.","label":"High Risk"}

sST2 is a soluble form of the ST2 protein, a member of the interleukin-1 receptor family, and is involved in inflammatory and fibrotic pathways associated with cardiovascular diseases.

Elevated levels of sST2 have been linked to increased risk of adverse cardiovascular events, such as heart failure and mortality, making it a valuable prognostic tool.

The reference range for sST2 is typically 0–35 ng/mL, and levels above this range may indicate a higher risk of cardiovascular complications.

Frequently asked questions

What is the clinical significance of sST2?
sST2 is used as a prognostic marker to assess the risk of adverse cardiovascular events and to monitor disease progression.
How is sST2 measured?
sST2 is measured through a blood test, with levels reported in ng/mL.
  1. 1
    Soluble ST2 in Heart FailureSource
  2. 2
    Role of sST2 in Cardiovascular DiseaseSource

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy