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Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)

Published: July 27, 2026Updated: August 25, 2026

TAFI is a biomarker that measures the level of thrombin-activatable fibrinolysis inhibitor in the blood, which plays a crucial role in regulating fibrinolysis.

Quick summary

TAFI is a coagulation biomarker that helps assess fibrinolysis regulation.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

Units
%
Clinical utility
diagnostic
Result kind
quantitative
FDA-cleared
Roche TAFI, Stago TAFI
interpretation: {"text":"May indicate an increased risk of bleeding due to enhanced fibrinolysis.","label":"Low TAFI"}; {"text":"May suggest an increased risk of thrombosis due to impaired fibrinolysis.","label":"High TAFI"}

Thrombin-activatable fibrinolysis inhibitor (TAFI) is an enzyme that plays a significant role in the coagulation cascade by modulating fibrinolysis. It is activated by thrombin and stabilizes blood clots by inhibiting fibrinolysis.

The TAFI test is used diagnostically to evaluate the risk of thrombosis and to monitor the effectiveness of anticoagulant therapy. It is particularly useful in assessing patients with a history of thrombotic events.

Reference values for TAFI typically range from 50% to 150%. Deviations from this range may indicate an increased risk of bleeding or thrombosis, depending on whether the levels are lower or higher than normal.

Frequently asked questions

What is the normal range for TAFI levels?
The normal range for TAFI levels is typically between 50% and 150%.
How is TAFI testing used in clinical practice?
TAFI testing is used to assess the risk of thrombosis and to monitor the effectiveness of anticoagulant therapy.
  1. 1
    Thrombin-activatable fibrinolysis inhibitor (TAFI)Source
  2. 2
    Role of TAFI in coagulation and fibrinolysisSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy